产品描述信息
NR-53789?? Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro)(Monoclonal Antibodies)|SARS Coronavirus|Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro)| -20°C to -80°C|Sino BiologicalAcknowledgment for publications should read “The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro), NR-53789.”|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Antibody Class: IgG1κ
Clone: D001
Chimeric monoclonal antibody prepared against the severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) glycoprotein receptor binding domain (RBD) was produced using recombinant antibody technology. The variable region was obtained from mice immunized with purified recombinant SARS-CoV spike RBD protein (Sino Biological 40150-V08B2) to produce the variable region, which was combined with constant domains of the human IgG1 molecule.
NR-53789 is specific to the SARS-CoV spike RBD protein and shows cross reactivity in ELISA with the SARS-CoV spike S1 protein, the SARS-CoV-2 spike RBD protein and the SARS-CoV-2 spike S1 protein, with no cross reactivity with the spike S1 proteins from MERS-CoV, HCoV-HKU1 (isolates N1 and N5), HCoV-NL63 or HCoV-229E, or the HCoV-OC43 spike S1 + S2 ectodomain (ECD) protein. The biological activity of NR-53789 was measured by its binding ability using biosensor analysis, in which immobilized recombinant SARS-CoV-2 spike RBD protein (His tag) (Sino Biological 40592-V08B-B) can bind NR-53789; the affinity constant is 0.12 nM.
Each vial of NR-53789 contains approximately 50 ?L of purified monoclonal antibody in phosphate buffered saline (PBS).
For more information please visit the
Sino Biological website.