NR-53789单克隆抗SARS冠状病毒/SARS相关冠状病毒2刺突糖蛋白受体结合域(RBD),嵌合抗体(体外生产)(单克隆抗体）
产品图片
货号/SKU
NR-53789
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、1
产品描述信息
NR-53789?? Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro)(Monoclonal Antibodies)|SARS Coronavirus|Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro)| -20°C to -80°C|Sino BiologicalAcknowledgment for publications should read “The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-SARS Coronavirus/SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Antibody (produced in vitro), NR-53789.”|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Antibody Class: IgG1κ
Clone: D001
Chimeric monoclonal antibody prepared against the severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) glycoprotein receptor binding domain (RBD) was produced using recombinant antibody technology. The variable region was obtained from mice immunized with purified recombinant SARS-CoV spike RBD protein (Sino Biological 40150-V08B2) to produce the variable region, which was combined with constant domains of the human IgG1 molecule.
NR-53789 is specific to the SARS-CoV spike RBD protein and shows cross reactivity in ELISA with the SARS-CoV spike S1 protein, the SARS-CoV-2 spike RBD protein and the SARS-CoV-2 spike S1 protein, with no cross reactivity with the spike S1 proteins from MERS-CoV, HCoV-HKU1 (isolates N1 and N5), HCoV-NL63 or HCoV-229E, or the HCoV-OC43 spike S1 + S2 ectodomain (ECD) protein. The biological activity of NR-53789 was measured by its binding ability using biosensor analysis, in which immobilized recombinant SARS-CoV-2 spike RBD protein (His tag) (Sino Biological 40592-V08B-B) can bind NR-53789; the affinity constant is 0.12 nM.
Each vial of NR-53789 contains approximately 50 ?L of purified monoclonal antibody in phosphate buffered saline (PBS).
For more information please visit the Sino Biological website.
Antibody Class: IgG1κ
Clone: D001
Chimeric monoclonal antibody prepared against the severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) glycoprotein receptor binding domain (RBD) was produced using recombinant antibody technology. The variable region was obtained from mice immunized with purified recombinant SARS-CoV spike RBD protein (Sino Biological 40150-V08B2) to produce the variable region, which was combined with constant domains of the human IgG1 molecule.
NR-53789 is specific to the SARS-CoV spike RBD protein and shows cross reactivity in ELISA with the SARS-CoV spike S1 protein, the SARS-CoV-2 spike RBD protein and the SARS-CoV-2 spike S1 protein, with no cross reactivity with the spike S1 proteins from MERS-CoV, HCoV-HKU1 (isolates N1 and N5), HCoV-NL63 or HCoV-229E, or the HCoV-OC43 spike S1 + S2 ectodomain (ECD) protein. The biological activity of NR-53789 was measured by its binding ability using biosensor analysis, in which immobilized recombinant SARS-CoV-2 spike RBD protein (His tag) (Sino Biological 40592-V08B-B) can bind NR-53789; the affinity constant is 0.12 nM.
Each vial of NR-53789 contains approximately 50 ?L of purified monoclonal antibody in phosphate buffered saline (PBS).
For more information please visit the Sino Biological website.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.此限制的订单将在发货前发送到NIAID批准.
抗体类：IgG1κ
克隆：D001
使用重组抗体技术制备针对严重急性呼吸综合征冠状病毒（SARS-COV）峰值的嵌合单克隆抗体.从用纯化的重组SARS-COV峰值峰RBD蛋白（SINO生物40150-V08B2）免疫的小鼠获得可变区以产生可变区，其与人IgG1分子的恒定结构域组合.
NR-53789特异于SARS-COV尖峰RBD蛋白，并显示ELISA的交叉反应性，SARS-COV-2尖峰RBD蛋白和SARS-COV-2穗S1蛋白，没有与来自MERS-COV，HCOV-HKU1（分离株N1和N5），HCOV-N16或HCOV-229E的尖峰S1蛋白的交叉反应性，或HCOV-OC43穗S1 + S2胞外（ECD）蛋白.通过使用生物传感器分析的结合能力测量NR-53789的生物活性，其中固定化的重组SARS-COV-2穗rBD蛋白（SINOG 40592-V08B-B）可以结合NR-53789;亲和力常数为0.12nm.
每个小瓶的NR-53789含有大约50μL磷酸盐缓冲盐水（PBS）的纯化的单克隆抗体.
有关更多信息，请访问 Sino Biological网站.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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