NR-48814蝙蝠SARS样冠状病毒,HKU5,重组,含有SARS冠状病毒,UrbaniSpike糖蛋白外域(病毒）
产品图片
货号/SKU
NR-48814
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、3
产品描述信息
NR-48814?? Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain(Viruses)|SARS coronavirus|Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain|-60°C or colder|RS BaricAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain, NR-48814."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Synthetic recombinant bat severe acute respiratory syndrome (SARS)-like coronavirus (CoV), HKU5, containing the spike glycoprotein ectodomain of the SARS-CoV Urbani strain (BtCoV HKU5-SE).
The complete genome of bat CoV HKU5 has been sequenced (GenBank: EF065512), as has the complete genome of SARS-CoV, Urbani (GenBank: AY278741), and a mouse-adapted variant (GenBank: DQ497008).
NR-48814 is a synthetic chimeric recombinant coronavirus based on a consensus bat SARS-like coronavirus (SCoV) sequence. The region of the bat SCoV genome encoding the spike (S) glycoprotein ectodomain was replaced with the corresponding region from the SARS-CoV, Urbani genome. A histidine for tyrosine substitution at position 436, previously shown to enhance replication in mice, was also included in the S gene. This virus replicates efficiently in cell culture and in young and aged mice, where the virus targets airway and alveolar epithelial cells.
Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero 76, clone E6: ATCC ? CRL-1586?) infected with BtCoV HKU5-SE.
Use of this material for any purpose by commercial or for profit entities requires a license from The University of North Carolina at Chapel Hill prior to shipment. For more information on obtaining a license to use this material please contact the UNC-CH Office of Technology Development, 100 Europa Drive, Suite 430, Chapel Hill, North Carolina 27517, Phone (919) 966-3929, Email: otd@unc.edu.
Synthetic recombinant bat severe acute respiratory syndrome (SARS)-like coronavirus (CoV), HKU5, containing the spike glycoprotein ectodomain of the SARS-CoV Urbani strain (BtCoV HKU5-SE).
The complete genome of bat CoV HKU5 has been sequenced (GenBank: EF065512), as has the complete genome of SARS-CoV, Urbani (GenBank: AY278741), and a mouse-adapted variant (GenBank: DQ497008).
NR-48814 is a synthetic chimeric recombinant coronavirus based on a consensus bat SARS-like coronavirus (SCoV) sequence. The region of the bat SCoV genome encoding the spike (S) glycoprotein ectodomain was replaced with the corresponding region from the SARS-CoV, Urbani genome. A histidine for tyrosine substitution at position 436, previously shown to enhance replication in mice, was also included in the S gene. This virus replicates efficiently in cell culture and in young and aged mice, where the virus targets airway and alveolar epithelial cells.
Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero 76, clone E6: ATCC ? CRL-1586?) infected with BtCoV HKU5-SE.
Use of this material for any purpose by commercial or for profit entities requires a license from The University of North Carolina at Chapel Hill prior to shipment. For more information on obtaining a license to use this material please contact the UNC-CH Office of Technology Development, 100 Europa Drive, Suite 430, Chapel Hill, North Carolina 27517, Phone (919) 966-3929, Email: otd@unc.edu.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.此限制的订单将在发货前发送到NIAID批准.
合成重组蝙蝠严重急性呼吸综合征（SARS） - 蓖麻病毒（COV），HKU5，含有SARS-COV Urbani菌株的穗糖蛋白突突（BTCOV HKU5-SE）.
BAT COV HKU5的完整基因组已被测序（GenBank：EF065512），SARS-COV，URBANI（GENBANK：AY278741）的完整基因组，以及鼠标适应变体（GENBANK：DQ497008）.
NR-48814是一种基于共有蝙蝠SARS样冠状病毒（SCOV）序列的合成嵌合重组冠状病毒.用来自SARS-COV，Urbani Genome的相应区域取代了编码穗糖蛋白胞外蛋白的蝙蝠Scov基因组区域.在S基因中也包括在第436位，以提高小鼠复制的位置436处的酪氨酸替代的组氨酸.该病毒有效地在细胞培养和年轻和老年小鼠中重复，病毒靶向气道和肺泡上皮细胞.
每个小瓶含有大约1ml的细胞裂解物和来自鞘膜藓酸的细胞裂解物和上清液肾上皮细胞（Vero 76，克隆E6：ATCC ? CRL-1586?）感染BTCOV HKU5- se.
通过商业或利润实体使用这种材料，需要在发货前北卡罗来纳大学的许可证.有关获取使用此材料的许可的更多信息，请联系Unc-Ch技术开发办公室，100欧罗巴驾驶，套房430，Chapel Hill，North Carolina 27517，Phone（919）966-3929，电子邮件： otd@unc.edu .
厂牌介绍
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BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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