产品描述信息
NR-31082?? Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1(Monoclonal Antibodies)|West Nile virus|Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1|-80°C upon arrival, 2°C to 8°C after thawing|NIAID/NIHAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1, NR-31082."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval.NR-31082 is a humanized IgG1, neutralizing monoclonal antibody that recognizes domain III of West Nile virus E protein, but not the E protein of other closely related flaviviruses. The antibody neutralizes West Nile virus in vitro and confers protective activity when administered pre- or post-exposure to West Nile virus-infected mice or hamsters. It is produced as a full length glycosylated immunoglobulin using a CHO cell line. The antibody consists of two identical light chain polypeptides of 23,329 daltons and two identical heavy chain polypeptides of 49,254 daltons. Column chromatographic procedures and filtration were used to purify the monoclonal antibody and to facilitate virus removal and inactivation.Each vial of NR-31082 contains approximately 1 mL of a sterile solution of monoclonal antibody MGAWN1 at a nominal concentration of 25 mg/mL. The solution also contains 10 mM sodium acetate, pH 5.1, with 9% sucrose (w/v) and 0.05 mg/mL polysorbate 80.