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产品图片
货号/SKU
NR-31082
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、1
产品描述信息
NR-31082?? Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1(Monoclonal Antibodies)|West Nile virus|Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1|-80°C upon arrival, 2°C to 8°C after thawing|NIAID/NIHAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-West Nile Virus E Protein, Clone MGAWN1 (Reference Lot 1-FIN-1027), Humanized IgG1, NR-31082."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval.
NR-31082 is a humanized IgG1, neutralizing monoclonal antibody that recognizes domain III of West Nile virus E protein, but not the E protein of other closely related flaviviruses. The antibody neutralizes West Nile virus in vitro and confers protective activity when administered pre- or post-exposure to West Nile virus-infected mice or hamsters. It is produced as a full length glycosylated immunoglobulin using a CHO cell line. The antibody consists of two identical light chain polypeptides of 23,329 daltons and two identical heavy chain polypeptides of 49,254 daltons. Column chromatographic procedures and filtration were used to purify the monoclonal antibody and to facilitate virus removal and inactivation.
Each vial of NR-31082 contains approximately 1 mL of a sterile solution of monoclonal antibody MGAWN1 at a nominal concentration of 25 mg/mL. The solution also contains 10 mM sodium acetate, pH 5.1, with 9% sucrose (w/v) and 0.05 mg/mL polysorbate 80.
NR-31082 is a humanized IgG1, neutralizing monoclonal antibody that recognizes domain III of West Nile virus E protein, but not the E protein of other closely related flaviviruses. The antibody neutralizes West Nile virus in vitro and confers protective activity when administered pre- or post-exposure to West Nile virus-infected mice or hamsters. It is produced as a full length glycosylated immunoglobulin using a CHO cell line. The antibody consists of two identical light chain polypeptides of 23,329 daltons and two identical heavy chain polypeptides of 49,254 daltons. Column chromatographic procedures and filtration were used to purify the monoclonal antibody and to facilitate virus removal and inactivation.
Each vial of NR-31082 contains approximately 1 mL of a sterile solution of monoclonal antibody MGAWN1 at a nominal concentration of 25 mg/mL. The solution also contains 10 mM sodium acetate, pH 5.1, with 9% sucrose (w/v) and 0.05 mg/mL polysorbate 80.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.超过此限制的订单将被发送到NIAID以进行批准. NR-31082是人源化IgG1，中和单克隆抗体，识别西尼罗河病毒E蛋白的结构域III，但不是E蛋白其他密切相关的黄病毒.该抗体中和西尼罗病毒在体外，在施用前或暴露于西尼罗河病毒感染的小鼠或仓鼠时赋予保护活动.它是使用CHO细胞系作为全长糖基化免疫球蛋白制备.该抗体由两种相同的轻链多肽组成23,329道尔顿和49,254道尔顿的两种相同的重链多肽.柱色谱方法和过滤用于纯化单克隆抗体并促进病毒去除和失活. 每个小瓶的NR-31082含有约1ml的单克隆抗体Mgawn1的无菌溶液，标称浓度为25 mg / ml.该溶液还含有10mM乙酸钠，pH5.1，具有9％蔗糖（W / V）和0.05mg / ml聚山梨醇酯80.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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