NR-14816流产布鲁氏菌,2308ΔwbkA(细菌）
产品图片
货号/SKU
NR-14816
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、3
产品描述信息
NR-14816??Brucella abortus, 2308 ΔwbkA(Bacteria)|Brucella abortus|2308 ΔwbkA|-60°C or colder|E ParamithiotisAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Brucella abortus, Strain 2308 ΔwbkA, NR-14816."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Brucella abortus (B. abortus), strain 2308 ΔwbkA was generated from strain 2308 by deletion of the wbkA gene and replacement with a marker gene encoding resistance to kanamycin. B. abortus, strain 2308 is a well-studied standard laboratory biovar 1 strain, isolated in the USA, that is known to be virulent for humans, cattle and other domestic animals.
The wbkA protein is an N-formyl-glutamine transferase that is essential to the biosynthesis of the LPS O antigen [locus tag: BAB_RS18565 (previously, locus tag: BAB1_0553)]. The wbkA deletion in B. abortus, strain 2308, resulted in the attenuation of the strain for infection of murine macrophages (RAW264.7) as determined by the contributor and others. It has also been noted that strain 2308 ΔwbkA can provide similar protection efficacy against challenge as the S19 vaccine. The complete genome sequence of B. abortus, strain 2308 is available (GenBank: JMRZ00000000).
Each vial contains approximately 0.7 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.
Brucella abortus (B. abortus), strain 2308 ΔwbkA was generated from strain 2308 by deletion of the wbkA gene and replacement with a marker gene encoding resistance to kanamycin. B. abortus, strain 2308 is a well-studied standard laboratory biovar 1 strain, isolated in the USA, that is known to be virulent for humans, cattle and other domestic animals.
The wbkA protein is an N-formyl-glutamine transferase that is essential to the biosynthesis of the LPS O antigen [locus tag: BAB_RS18565 (previously, locus tag: BAB1_0553)]. The wbkA deletion in B. abortus, strain 2308, resulted in the attenuation of the strain for infection of murine macrophages (RAW264.7) as determined by the contributor and others. It has also been noted that strain 2308 ΔwbkA can provide similar protection efficacy against challenge as the S19 vaccine. The complete genome sequence of B. abortus, strain 2308 is available (GenBank: JMRZ00000000).
Each vial contains approximately 0.7 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.在此限制上订单将在发货前发送至NIAID进行批准. Brucella abortus（B. abortus），菌株2308δ WBKA 通过缺失 WBKA 基因和用编码对卡那霉素的抗性的标志物基因替代. b. Abortus ，菌株2308是一家学习的标准实验室Biovar 1菌株，众所周知，众所周知的人类，牛和其他家畜的毒性. WBKA蛋白是一种N-甲酰基 - 谷氨酰胺转移酶对LPS o抗原的生物合成至关重要[洛卡斯标签：BAB_RS18565（以前，轨迹标签：BAB1_0553）]. wbka 在 b中删除. Abortus ，菌株2308导致由贡献者和其他人确定的鼠巨噬细胞（RAW264.7）感染的菌株的衰减.还应注意到应变2308δ WBKA 可以为S19疫苗提供类似的保护效果. b的完整基因组序列. abortus ，应变2308可用（genbank： jmrz00000000 ）. 每个小瓶在补充有10％甘油的胰蛋白酶大豆肉汤中含有大约0.7毫升的细菌培养.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
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BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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