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Buy direct from the manufacturer. Bulk quantity available.
MW: 29,000 Extinction Coefficient: 1.0
Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation.
Storage:
Purity: >= 95% by SDS-PAGE.
Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Lab products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
Product Citations: Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, et al. Modulation of γδ T cell activation by neutrophil elastase. Immunology. 2017 Sep 9. doi: 10.1111/imm.12835. [Epub ahead of print]
Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, et al. Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles. J Biol Chem. 2016 May 13;291(20):10476-89. doi: 10.1074/jbc.M115.698639. Epub 2016 Mar 9.
Schreiber A, Eulenberg-Gustavus C, Bergmann A, Jerke U, Kettritz R. Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice. J Leukoc Biol. 2016 Dec;100(6):1443-1452. Epub 2016 Jun 30.
Barauskas O, et al. Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir. Biochim Biophys Acta. 2014 Dec;1840(12):3292-8. doi: 10.1016/j.bbagen.2014.08.002. Epub 2014 Aug 17.
