MRA-712A_单克隆抗体R218抗恶性疟原虫红细胞结合抗原175RII(体外生产)(单克隆抗体）

MRA-712A?? Monoclonal Antibody R218 Anti-Plasmodium falciparum Erythrocyte Binding Antigen-175 RII (produced in vitro)(Monoclonal Antibodies)|Plasmodium falciparum|Monoclonal Antibody R218 Anti-Plasmodium falciparum Erythrocyte Binding Antigen-175 RII (produced in vitro)|-20°C or colder| BKL Sim, NIAID/NIHAcknowledgment for publications should read “The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Antibody R218 Anti-Plasmodium falciparum Erythrocyte Binding Antigen-175 RII (produced in vitro), MRA-712A, contributed by B. Kim Lee Sim and NIAID/NIH.”|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment. Antibody Class: IgG1κ Monoclonal antibody R218 prepared against the erythrocyte binding antigen (EBA)-175 of Plasmodium falciparum (P. falciparum) 3D7 was purified from mouse hybridoma supernatant by protein G affinity chromatography. The monoclonal antibody R218 recognizes a conformation-dependent epitope located within the F1 domain of region II (RII), more strongly under non-reducing conditions. EBA-175 is a 175 kDa, P. falciparum parasite ligand at the apical end of the merozoite that binds to its receptor glycophorin A on the surface of erythrocytes in a sialic acid-dependent manner. MRA-712A is functional in western blot, immunofluorescence and ELISA assays. Each vial contains approximately 50 ?L of purified monoclonal antibody in PBS pH 7.2.