NR-28526_人类呼吸道合胞病毒

NR-28526??Human respiratory syncytial virus, A2001/3-12(Viruses)|Human respiratory syncytial virus|A2001/3-12|-60°C or colder|ML MooreAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Human Respiratory Syncytial Virus, A2001/3-12, NR-28526."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment. Human respiratory syncytial virus (RSV), A2001/3-12 was isolated from a nasal wash from an infant with RSV bronchiolitis in Nashville, Tennessee, USA, on March 12, 2001. A2001/3-12 is one of six clinical RSV isolates that recently were shown to induce variable disease severity, lung interleukin-13 (IL-13) levels, and gob-5 levels in BALB/cJ mice. IL-13 is a cytokine linked to mucus production and gob-5 is a calcium-activated chloride channel family member implicated in airway inflammation. Compared to mock infection, RSV, A2001/3-12 infection led to relatively low levels of gob-5 in lung tissue, and no significant elevation in IL-13 expression, but did induce early weight loss and lung damage in infected mice. The complete genome of RSV, A2001/3-12 has been sequenced (GenBank: JX069799). Each vial contains approximately 1 mL of cell lysate and supernatant from HEp-2 cells infected with human respiratory syncytial virus, A2001/3-12. Additional information and tools are available at ViPR (Virus Pathogen Resource).