产品图片
产品别名
货号/SKU
EWL005
货号/规格
100uL
库存与交货期
1-2周
人民币价格
10285
试剂海关审批
使用人负责A/B风险申请资质
国外采购
支持/部分需签MTA
厂牌
Kerafast, Inc.
品牌
产品基础信息
From the laboratory of Jeffrey H. Miner, PhD, Washington University in Saint Louis.
产品描述信息
Product Type: | Antibody |
Accession ID: | NP_001074640.1 |
Antigen: | Laminin Α5, laminin alpha5, LAMA5 |
Molecular Weight: | 400 kDa |
Clonality: | Polyclonal |
Clone Name: | Serum 8948 and 1586 |
Reactivity: | Mouse, rat; not human or rabbit or chicken |
Immunogen: | Recombinant mouse protein made in bacteria |
Species Immunized: | Rabbit |
Epitope: | Portions of domains LEb + L4b of mouse LAMA5 |
Buffer: | Whole serum |
Tested Applications: | WB 1:1000, IHC 1:800; NOTE: Both antibodies work fine by immunofluorescence, but 1586 was deemed better for Western blotting. |
Storage: | -80C |
Shipped: | Dry Ice |
产品安全信息
Miner JH, Cunningham J, Sanes JR: Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol 143: 1713-1723, 1998.Miner JH, Li C: Defective glomerulogenesis in the absence of laminin a5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol 217: 278-289, 2000.Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol 137: 685-701, 1997.Shannon MB, Patton BL, Harvey SJ, Miner JH: A hypomorphic mutation in the mouse Laminin alpha5 gene (Lama5) causes polycystic kidney disease. J Am Soc Nephrol 17: 1913-1922, 2006.Kikkawa Y, Miner JH: Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function. Dev Biol 296: 265-277, 2006.Kikkawa Y, Moulson CL, Virtanen I, Miner JH: Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. J Biol Chem 277: 44864-44869, 2002.Kikkawa Y, Virtanen I, Miner JH: Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol 161: 187-196, 2003.Moulson CL, Li C, Miner JH: Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo. Dev Dyn 222: 101-114, 2001.Bolcato-Bellemin AL, Lefebvre O, Arnold C, Sorokin L, Miner JH, Kedinger M, Simon-Assmann P: Laminin alpha5 chain is required for intestinal smooth muscle development. Dev Biol 260: 376-390, 2003.Nguyen NM, Kelley DG, Schlueter JA, Meyer MJ, Senior RM, Miner JH: Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282: 111-125, 2005.Nguyen NM, Miner JH, Pierce RA, Senior RM: Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. Dev Biol 246: 231-244, 2002.St. John PL, Abrahamson DR: Glomerular endothelial cells and podocytes jointly synthesize laminin-1 and -11 chains. Kidney Int 60: 1037-1046, 2001.St. John PL, Wang R, Yin Y, Miner JH, Robert B, Abrahamson DR: Glomerular laminin isoform transitions: errors in metanephric culture are corrected by grafting. Am J Physiol Renal Physiol 280: F695-705, 2001.Pierce RA, Griffin GL, Mudd MS, Moxley MA, Longmore WJ, Sanes JR, Miner JH, Senior RM: Expression of laminin alpha3, alpha4, and alpha5 chains by alveolar epithelial cells and fibroblasts. Am J Respir Cell Mol Biol 19: 237-244, 1998.Meehan DT, Delimont D, Dufek B, Zallocchi M, Phillips G, Gratton MA, Cosgrove D: Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. Hear Res 341: 100-108, 2016.Imanishi H, Tsuruta D, Tateishi C, Sugawara K, Kobayashi H, Ishii M, Kishi K: Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis. Med Mol Morphol 47: 38-42, 2014.Kim ST, Adair-Kirk TL, Senior RM, Miner JH: Functional Consequences of Cell Type-Restricted Expression of Laminin alpha5 in Mouse Placental Labyrinth and Kidney Glomerular Capillaries. PLoS ONE 7: e41348, 2012.If you publish research with this product, please let us know so we can cite your paper.
主要内容
兔多克隆抗体对细菌制成的重组小鼠蛋白质产生并与小鼠和大鼠α5反应反应揭幕和免疫组织化学应用于圣路易斯华盛顿大学博士的Jeffrey H. Miner实验室。
厂牌介绍
关于Kerafast Inc.
Kerafast 是一家位于波士顿的试剂公司,其主要使命是为QuanQiu科学界提供易于使用的独特实验室研究工具。我们的产品组合包括细胞系、抗体、小分子、染料等,其中许多在其他地方无法获得。自 2011 年成立以来,来自全球 190 多个机构的研究人员通过我们的在线平台提供了他们的创新试剂,无需通过传统的材料转让协议流程即可快速获取材料。
我们处理提供实验室的所有销售和运输物流,并从每次销售中返还丰厚的特许权使用费。因此,我们帮助提供实验室节省时间和资源,同时为进一步研究提供额外资金。采购科学家可以更轻松地发现和获取其他地方通常无法获得的独特试剂,同时还可以资助其他研究人员的工作。这创建了一个QuanQiu科学家社区,他们贡献和获取Reagent for the Greater Good,以加速他们自己的研究以及整体科学进步。
2018 年,Kerafast 与Absolute Antibody合并,后者是一家总部位于英国的公司,其愿景是为所有研究人员提供重组抗体技术。此次合并将两家公司聚集在一起,共同致力于改善科学界可用的研究工具的选择。
品牌标识
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