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Synonym: ATIII, Antithrombin, AT, Factor Xa inhibitor, Heparin cofactor
MW: 58,000
Extinction Coefficient: 0.65
Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl.
Storage:
Purified Native Human Antithrombin III, Human Plasma
Bulk Qty Available.
Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Functions in the inhibition of the proteolytic enzymes involved in blood coagulation and fibrinolysis, including factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin. Clinically, reduced levels are indicative of hypercoagulability.
Purity: >=95% by SDS-PAGE
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Lab products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.
Product Citation:
Perera, Natascha C., Oliver Schilling, Heike Kittel, Walter Back, Elisabeth Kremmer, and Dieter E. Jenne. "NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proceedings of the National Academy of Sciences 109, no. 16 (2012): 6229-6234.
Guo C, et al.
High-resolution probing heparan sulfate–antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies.
Phys Chem Chem Phys. 2015 May 28;17(20):13301-6. doi: 10.1039/c5cp01305d.
Tafaleng EN, et al.
Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency.
Hepatology. 2015 Jul;62(1):147-57. doi: 10.1002/hep.27753. Epub 2015 Apr 13.
