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产品图片
货号/SKU
NR-50414
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、1
产品描述信息
NR-50414?? Monoclonal Anti-Zika Virus Envelope (E) Protein, Clone ZV-2 (produced in vitro)(Monoclonal Antibodies)|Zika virus|Monoclonal Anti-Zika Virus Envelope (E) Protein, Clone ZV-2 (produced in vitro)|-20°C or colder|MS DiamondAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-Zika Virus Envelope (E) Protein, Clone ZV-2 (produced in vitro), NR-50414."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Antibody Class: IgG2cκ
Mouse monoclonal antibody prepared against the envelope (E) glycoprotein of Zika virus (ZIKV) was purified from clone ZV-2 hybridoma supernatant by protein G affinity chromatography. The B cell hybridoma was generated by the fusion of P3X63Ag8.653 mouse myeloma cells with immunized mouse splenocytes. The ZV-2 antibody is non-neutralizing, recognizes an epitope within the ABDE sheet of the DIII domain of the E glycoprotein, and does not cross-react on dengue, Japanese encephalitis, or West Nile viruses.
Each vial of NR-50414 contains approximately 100 ?L of purified monoclonal antibody in phosphate-buffered saline, pH 7.4.
NR-50414 specifically recognizes ZIKV-infected cells in indirect immunofluorescence assays. The clone ZV-2 antibody is also reported to function in ELISA and in western blot assays performed under non-reducing conditions.
NR-50414 is claimed in U.S. Provisional Patent Application number 62/366,782 and the continuations, continuations-in-part, re-issues, and foreign counterparts thereof. For-profit entities wishing to obtain this material must confirm in writing to BEI Resources that they have executed a licensing agreement with the Contributor’s institution. Please contact the Office of Technology Management of the Washington University in St. Louis directly at mta@dom.wustl.edu.
Antibody Class: IgG2cκ
Mouse monoclonal antibody prepared against the envelope (E) glycoprotein of Zika virus (ZIKV) was purified from clone ZV-2 hybridoma supernatant by protein G affinity chromatography. The B cell hybridoma was generated by the fusion of P3X63Ag8.653 mouse myeloma cells with immunized mouse splenocytes. The ZV-2 antibody is non-neutralizing, recognizes an epitope within the ABDE sheet of the DIII domain of the E glycoprotein, and does not cross-react on dengue, Japanese encephalitis, or West Nile viruses.
Each vial of NR-50414 contains approximately 100 ?L of purified monoclonal antibody in phosphate-buffered saline, pH 7.4.
NR-50414 specifically recognizes ZIKV-infected cells in indirect immunofluorescence assays. The clone ZV-2 antibody is also reported to function in ELISA and in western blot assays performed under non-reducing conditions.
NR-50414 is claimed in U.S. Provisional Patent Application number 62/366,782 and the continuations, continuations-in-part, re-issues, and foreign counterparts thereof. For-profit entities wishing to obtain this material must confirm in writing to BEI Resources that they have executed a licensing agreement with the Contributor’s institution. Please contact the Office of Technology Management of the Washington University in St. Louis directly at mta@dom.wustl.edu.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.此限制的订单将在发货前发送到NIAID进行批准. 抗体类：IgG2C κ 小鼠单克隆抗体通过蛋白G亲和色谱法从克隆ZV-2杂交瘤上清液中纯化Zika病毒（Zikv）的封套（e）糖蛋白.通过P3X63AG8.653小鼠骨髓瘤细胞的融合产生B细胞杂交瘤，具有免疫小鼠脾细胞. ZV-2抗体是不中和的，识别出E糖蛋白的DIII结构域的ABDE片内的表位，并且不会在登革热，日本脑炎或西尼罗病毒上交叉反应. 小瓶NR-50414在磷酸盐缓冲盐水中含有约100μl纯化的单克隆抗体，pH7.4. NR-50414专门识别间接免疫荧光测定中的Zikv感染细胞.克隆ZV-2抗体还报告在ELISA中起作用，并在非还原条件下进行的蛋白质印迹测定. NR-50414在美国临时索赔
专利申请号62/366,782和持续，持续 - 部分，
重新发布和外国同行.
希望获得此材料的营利性实体必须确认
写信给北京资源，他们已经执行了许可协议
贡献者的机构.请
联系华盛顿大学技术管理办公室在圣.
路易斯直接在 mta@dom.wustl.edu .
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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