Yin Y*, Liu YX, Jin YJ, Hall EJ, Barrett JC. PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. NATURE, 422:527-531, 2003.

root 提交于 周日, 10/31/2021 - 01:47
Abstract p53 has a role in many cellular processes through the transcriptional regulation of target genes. PAC1 (phosphatase of activated cells 1; also known as dual specificity phosphatase 2, DUSP2) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates mitogen-activated protein (MAP) kinases. Here we show that during apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter. PAC1 transcription is induced in response to serum deprivation and oxidative stress, which results in p53-dependent apoptosis, but not in response to gamma-irradiation, which causes cell cycle arrest. Reduction of PAC1 transcription using small interfering RNA inhibits p53-mediated apoptosis, whereas overexpression of PAC1 increases susc......

相关内容

发布日期 10/08/2023 - 23:02
发布日期 06/17/2022 - 10:21
发布日期 01/11/2025 - 20:33
发布日期 12/08/2024 - 19:03
发布日期 01/10/2022 - 19:31
发布日期 01/10/2022 - 19:31
发布日期 08/17/2023 - 22:14
发布日期 10/29/2024 - 19:43
发布日期 04/26/2024 - 09:35
发布日期 06/17/2022 - 10:21