NR-48813人类冠状病毒、中东呼吸综合征冠状病毒、ORF5红色荧光蛋白替代重组传染性克隆(icMERS-CoV-RFP-ΔORF5)(病毒）
产品图片
货号/SKU
NR-48813
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、3
产品描述信息
NR-48813??Human coronavirus, Middle East Respiratory Syndrome Coronavirus, Recombinant Infectious Clone with ORF5 Red Fluorescent Protein Replacement (icMERS-CoV-RFP-ΔORF5)(Viruses)|Human coronavirus|Middle East Respiratory Syndrome Coronavirus, Recombinant Infectious Clone with ORF5 Red Fluorescent Protein Replacement (icMERS-CoV-RFP-ΔORF5)|-60°C or colder|RS BaricAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Middle East Respiratory Syndrome Coronavirus, Recombinant Infectious Clone with ORF5 Red Fluorescent Protein Replacement (icMERS-CoV-RFP-ΔORF5), NR-48813."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Recombinant infectious clone with ORF5 red fluorescent protein replacement (icMERS-CoV-RFP-ΔORF5).
NR-48813 is an engineered recombinant coronavirus based on the MERS-CoV, EMC2012 genome. The group-specific MERS-CoV accessory gene ORF5 was deleted and replaced with a synthetic gene encoding red fluorescent protein. The individual MERS-CoV group-specific ORFs are not essential for virus replication, although the absence of these genes as a group does attenuate peak viral titers. The MERS-CoV ORF5 accessory protein was recently shown to be a potent interferon antagonist.
ATCC ? employs Biosafety Level 3 facilities with enhanced practices and procedures for research and production activities utilizing genetically modified MERS coronaviruses.
Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero: ATCC ? CCL-81?) infected with icMERS-CoV-RFP-ΔORF5.
Additional information and tools are available at ViPR (Virus Pathogen Resource).
Use of this material for any purpose by commercial or for profit entities requires a license from The University of North Carolina at Chapel Hill prior to shipment. For more information on obtaining a license to use this material please contact the UNC-CH Office of Technology Development, 100 Europa Drive, Suite 430, Chapel Hill, North Carolina 27517, Phone (919) 966-3929, Email: otd@unc.edu.
Recombinant infectious clone with ORF5 red fluorescent protein replacement (icMERS-CoV-RFP-ΔORF5).
NR-48813 is an engineered recombinant coronavirus based on the MERS-CoV, EMC2012 genome. The group-specific MERS-CoV accessory gene ORF5 was deleted and replaced with a synthetic gene encoding red fluorescent protein. The individual MERS-CoV group-specific ORFs are not essential for virus replication, although the absence of these genes as a group does attenuate peak viral titers. The MERS-CoV ORF5 accessory protein was recently shown to be a potent interferon antagonist.
ATCC ? employs Biosafety Level 3 facilities with enhanced practices and procedures for research and production activities utilizing genetically modified MERS coronaviruses.
Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero: ATCC ? CCL-81?) infected with icMERS-CoV-RFP-ΔORF5.
Additional information and tools are available at ViPR (Virus Pathogen Resource).
Use of this material for any purpose by commercial or for profit entities requires a license from The University of North Carolina at Chapel Hill prior to shipment. For more information on obtaining a license to use this material please contact the UNC-CH Office of Technology Development, 100 Europa Drive, Suite 430, Chapel Hill, North Carolina 27517, Phone (919) 966-3929, Email: otd@unc.edu.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.此限制的订单将在发货前发送到NIAID批准.
具有ORF5红色荧光蛋白替代的重组传染性克隆（ICMERS-COV-RFP-ΔORF5）.
NR-48813是一种基于MERS-COV，EMC2012基因组的工程重组冠状病毒.删除组特异性MERS-COV辅助基因ORF5并用编码红色荧光蛋白的合成基因替换.特异性MERS-COV组特异性ORF对病毒复制不是必需的，尽管没有这些基因作为一个组确实衰减峰病毒滴度.最近显示MERS-COV ORF5辅助蛋白是有效的干扰素拮抗剂.
ATCC ?采用生物安全3级设施，利用转基因MERS冠状病毒的研究和生产活动的增强型实践和程序.
每个小瓶含有大约1ml的细胞裂解物和来自 Cercopithecus Aethiops的上清液，肾上皮细胞（Vero：ATCC ?CCL-812）感染ICMers-CoV-RFP-ΔORF5 .
vipr （病毒病原体资源）提供了附加信息和工具.
通过商业或利润实体使用这种材料，需要在发货前北卡罗来纳大学的许可证.有关获取使用此材料的许可的更多信息，请联系Unc-Ch技术开发办公室，100欧罗巴驾驶，套房430，Chapel Hill，North Carolina 27517，Phone（919）966-3929，电子邮件： otd@unc.edu .
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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