NR-28528_人类呼吸道合胞病毒

NR-28528??Human Respiratory Syncytial Virus, A1998/12-21(Viruses)|Human Respiratory Syncytial Virus|A1998/12-21|-60°C or colder|ML MooreAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Human Respiratory Syncytial Virus, A1998/12-21, NR-28528.”|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment. Human respiratory syncytial virus (RSV), A1998/12-21 was isolated from a nasal wash from an infant with RSV bronchiolitis in Nashville, Tennessee on December 12, 1998. A1998/12-21 is one of six clinical RSV isolates that recently were shown to induce variable disease severity, lung interleukin-13 (IL-13) levels, and gob-5 levels in BALB/cJ mice. IL-13 is a cytokine linked to mucus production and gob-5 is a calcium-activated chloride channel family member implicated in airway inflammation. Compared to mock infection, RSV A1998/12-21 infection led to relatively high levels of gob-5 in lung tissue, but no significant elevation in IL-13 expression, and no weight loss in infected mice. The complete genome of hRSV, A1998/12-21 has been sequenced (GenBank: JX069802.1). Each vial contains approximately 1 mL of cell lysate and supernatant from Homo sapiens epithelial carcinoma cells (HEp-2; ATCC ^? CCL-23?) infected with hRSV, A1998/12-21. Additional information and tools are available at ViPR (Virus Pathogen Resource).