NR-55410单克隆抗SARS相关冠状病毒2刺突糖蛋白受体结合域(RBD),嵌合强效中和抗体(体外生产)(单克隆抗体）
产品图片
货号/SKU
NR-55410
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、1
产品描述信息
NR-55410?? Monoclonal Anti-SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Potent Neutralizing Antibody (produced in vitro)(Monoclonal Antibodies)|SARS-Related Coronavirus 2|Monoclonal Anti-SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Potent Neutralizing Antibody (produced in vitro)| -70°C or colder |ACROBiosystemsAcknowledgment for publications should read “The following reagent was obtained through BEI Resources, NIAID, NIH: Monoclonal Anti-SARS-Related Coronavirus 2 Spike Glycoprotein Receptor Binding Domain (RBD), Chimeric Potent Neutralizing Antibody (produced in vitro), NR-55410.”|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
This item is currently in our production queue. Please allow ample time for distribution lots to be made available.
Antibody Class: IgG1κ
Chimeric monoclonal antibody prepared against the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein receptor binding domain (RBD) was produced using recombinant antibody technology. The variable region was obtained from immunized mice, which was combined with constant domains of the human IgG1 molecule.
NR-55410 is specific against SARS-CoV-2 S protein RBD; no cross-reactivity was detected with S protein RBD of other coronaviruses. NR-55410 has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 S glycoprotein with a neutralization titer of 0.03255 nM. The biological activity of NR-55410 was measured by its binding ability in an ELISA, in which immobilized SARS-CoV-2 S protein RBD (ACROBiosystems SPD-C52H3) at 1 ?g per mL (100 ?L per well) can bind NR-55410; the linear range is 0.05 to 0.78 ng per mL. The neutralizing activity of NR-55410 was measured in dose-response curves with a SARS-CoV-2 inhibitor screening kit (ACROBiosystems EP-105) with a half maximal inhibitory concentration (IC50) of 1.197 ?g per mL and with multiple S glycoprotein mutants. The biological activity of NR-55410 was also measured by its binding ability using biosensor analysis, in which loaded NR-55410 can bind SARS-CoV-2 S1 protein (ACROBiosystems S1N-C52H4); the affinity constant is 4.42 nM by ForteBio Octet Red96e.
Each vial of NR-55410 contains approximately 100 ?g of purified monoclonal antibody in phosphate buffered saline (PBS), pH 7.4 with 10% trehalose.
This item is currently in our production queue. Please allow ample time for distribution lots to be made available.
Antibody Class: IgG1κ
Chimeric monoclonal antibody prepared against the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein receptor binding domain (RBD) was produced using recombinant antibody technology. The variable region was obtained from immunized mice, which was combined with constant domains of the human IgG1 molecule.
NR-55410 is specific against SARS-CoV-2 S protein RBD; no cross-reactivity was detected with S protein RBD of other coronaviruses. NR-55410 has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 S glycoprotein with a neutralization titer of 0.03255 nM. The biological activity of NR-55410 was measured by its binding ability in an ELISA, in which immobilized SARS-CoV-2 S protein RBD (ACROBiosystems SPD-C52H3) at 1 ?g per mL (100 ?L per well) can bind NR-55410; the linear range is 0.05 to 0.78 ng per mL. The neutralizing activity of NR-55410 was measured in dose-response curves with a SARS-CoV-2 inhibitor screening kit (ACROBiosystems EP-105) with a half maximal inhibitory concentration (IC50) of 1.197 ?g per mL and with multiple S glycoprotein mutants. The biological activity of NR-55410 was also measured by its binding ability using biosensor analysis, in which loaded NR-55410 can bind SARS-CoV-2 S1 protein (ACROBiosystems S1N-C52H4); the affinity constant is 4.42 nM by ForteBio Octet Red96e.
Each vial of NR-55410 contains approximately 100 ?g of purified monoclonal antibody in phosphate buffered saline (PBS), pH 7.4 with 10% trehalose.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.通过此限制的订单将在发货前发送至NIAID进行批准.
此项目目前处于我们的生产队列中.请允许充足的时间进行分销批次.
抗体类：IgG1κ
使用重组抗体技术制备针对严重急性呼吸综合征相关的冠状病毒2（SARS-COV-2）峰值受体结合结构域（RBD）制备的嵌合单克隆抗体.从免疫小鼠获得可变区，其与人IgG1分子的恒定结构域组合.
NR-55410针对SARS-COV-2 S蛋白质RBD特异;没有其他冠状虫病毒的S蛋白质RBD检测过反应性. NR-55410对副病毒轴承SARS-COV-2S糖蛋白具有效力中和活性，其中中和滴度为0.03255nm.通过其在ELISA中的结合能力测量NR-55410的生物活性，其中将SARS-COV-2 S蛋白RBD（Acriobiosystems SPD-C52H3）固定在1μg/ mL（每孔100μl）中可以结合NR-55410 ;线性范围为0.05至0.78ng / ml. NR-55410的中和活性以剂量 - 反应曲线测量，SARS-COV-2抑制剂筛查试剂盒（辅助系统EP-105），半最大抑制浓度（IC 50）为每mL的1.197μg和多个糖蛋白突变体.通过使用生物传感器分析的其结合能力，也通过其结合能力来测量NR-55410的生物活性，其中加载的NR-55410可以粘合SARS-COV-2 S1蛋白（Acrobiosystems S1N-C52H4）; Fortebio Octet Red96e的亲和力常数为4.42nm.
每个小瓶NR-55410含有大约100μg的纯化的单克隆抗体，磷酸盐缓冲盐水（PBS），pH 7.4，具有10％海藻糖.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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