抗神经节苷脂GD2 [ME361]抗体

产品图片
货号/SKU
EWI023
货号/规格
100ug
库存与交货期
1-2周
人民币价格
10615
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试剂海关审批
使用人负责A/B风险申请资质
国外采购
支持/部分需签MTA
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Kerafast, Inc.
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产品基础信息
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
产品描述信息

Product Type: Antibody
Antigen: Ganglioside GD2
Accession ID: CAS Number 65988-71-8; bDGalpNAc(1-4)[aNeu5Ac(2-8)aNeu5Ac(2-3)]bDGalp(1-4)bDGlcp(1-1)Cer
Isotype: IgG2a/kappa
Clonality: Monoclonal
Clone Name: ME361 / ME36.1
Reactivity: Human
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: FACS (1:50), IHC (1:50), Binding assays (1:50)
Storage: -20C
Shipped: Cold packs
产品安全信息
Ahmed M, Cheung NK. Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy. FEBS Lett. 2014 Jan 21;588(2):288-97. Herlyn M, Thurin J, Balaban G, Bennicelli JL, Herlyn D, Elder DE, Bondi E, Guerry D, Nowell P, Clark WH, et al. Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res. 1985 Nov;45(11 Pt 2):5670-6. Iliopoulos, D; Ernst, C; Steplewski, Z; Jambrosic, J A; Rodeck, U; Herlyn, M; Clark, W H; Koprowski, H; Herlyn, D. Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides.J Natl Cancer Inst. 1989 03 15;81(6):440-4Pichla, S L; Murali, R; Burnett, R M. The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.J Struct Biol. 1997 06;119(1):6-16Pichla, S L; Murali, R; Burnett, R M. Preliminary crystallographic data for an Fab to the melanoma-associated GD2 ganglioside, and the purification of a soluble form of this antigen.Acta Crystallogr D Biol Crystallogr. 1995 01 01;51(Pt 1):124-6Kieber-Emmons, Thomas; Monzavi-Karbassi, Bejatohlah; Pashov, Anastas; Saha, Somdutta; Murali, Ramachandran; Kohler, Heinz. The promise of the anti-idiotype concept.Front Oncol. 2012;2:196Vázquez, Ana M H; Rodrèguez-Zhurbenko, Nely; López, Ana M V. Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry.Front Oncol. 2012;2:170Agostino, Mark; Yuriev, Elizabeth; Ramsland, Paul A. Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping.PLoS One. 2012;7(4):e35457Ahmed, Mahiuddin; Goldgur, Yehuda; Hu, Jian; Guo, Hong-Fen; Cheung, Nai-Kong V. In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors.PLoS One. 2013;8(5):e63359Cheung, Nai-Kong V; Guo, Hongfen; Hu, Jian; Tassev, Dimiter V; Cheung, Irene Y. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo.Oncoimmunology. 2012 07 01;1(4):477-486Bernhard, H; Karbach, J; Strittmatter, W; Meyer Zum Büschenfelde, K H; Knuth, A. Induction of tumor-cell lysis by bi-specific antibody recognizing ganglioside GD2 and T-cell antigen CD3.Int J Cancer. 1993 09 30;55(3):465-70Ruf, Peter; Schäfer, Beatrix; Eissler, Nina; Mocikat, Ralph; Hess, Juergen; Plöscher, Matthias; Wosch, Susanne; Suckstorff, Ivonne; Zehetmeier, Christine; Lindhofer, Horst. Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model.J Transl Med. 2012 11 07;10:219Kieber-Emmons, Thomas; Saha, Somdutta; Pashov, Anastas; Monzavi-Karbassi, Behjatolah; Murali, Ramachandran. Carbohydrate-mimetic peptides for pan anti-tumor responses.Front Immunol. 2014;5:308Wondimu, Assefa; Zhang, Tianqian; Kieber-Emmons, Thomas; Gimotty, Phyllis; Sproesser, Katrin; Somasundaram, Rajasekharan; Ferrone, Soldano; Tsao, Chun-Yen; Herlyn, Dorothee. Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice.Cancer Immunol Immunother. 2008 07;57(7):1079-89Dobrenkov, Konstantin; Cheung, Nai-Kong V. GD2-targeted immunotherapy and radioimmunotherapy.Semin Oncol. 2014 10;41(5):589-612Díaz-Zaragoza, Mariana; Hernández-Ávila, Ricardo; Viedma-Rodríguez, Rubí; Arenas-Aranda, Diego; Ostoa-Saloma, Pedro. Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer (Review).Oncol Rep. 2015 09;34(3):1106-14Somasundaram, Rajasekharan; Caputo, Laura; Guerry, DuPont; Herlyn, Dorothee. CD8+, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma.J Transl Med. 2005 11 10;3:41Doronin, Igor I; Vishnyakova, Polina A; Kholodenko, Irina V; Ponomarev, Eugene D; Ryazantsev, Dmitry Y; Molotkovskaya, Irina M; Kholodenko, Roman V. Ganglioside GD2 in reception and transduction of cell death signal in tumor cells.BMC Cancer. 2014 04 28;14:295Cheng, Ming; Ahmed, Mahiuddin; Xu, Hong; Cheung, Nai-Kong V. Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy.Int J Cancer. 2015 01 15;136(2):476-86Deppisch, Nina; Ruf, Peter; Eißler, Nina; Lindhofer, Horst; Mocikat, Ralph. Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition.Oncotarget. 2017 01 17;8(3):4520-4529Airoldi, I; Lualdi, S; Bruno, S; Raffaghello, L; Occhino, M; Gambini, C; Pistoia, V; Corrias, M V. Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L.Br J Cancer. 2003 05 19;88(10):1527-36If you publish research with this product, please let us know so we can cite your paper.
主要内容
这种小鼠IgG单克隆抗体识别人神经节苷脂Gd2.highlights:人神经节苷脂的特异性Gd2对GD3具有低亲和力,所述GD3存在于包括黑素瘤Me 36.1的几种神经分区肿瘤上,已被发现抑制接种位点的肿瘤生长,以及转移扩散在适用于FACS,免疫组织化学和结合试验期间的临床前研究中的淋巴结和肺部是阳化GD2,是含唾液酸的糖磷脂,其参与细胞附着于细胞外基质。 GD2对神经母细胞瘤,视网膜母细胞瘤,黑素瘤,小细胞肺癌,脑肿瘤,骨肉瘤,横纹肌瘤组织过度表达。 GD2定位于细胞表面。已显示GD2以增强骨骼肉瘤和小细胞肺癌细胞中的肿瘤增殖和侵袭性。从Meenhard覆盖,DVM,DSC,Wistar Institute的实验室。部分调查员的附件计划。
厂牌介绍

关于Kerafast Inc.

Kerafast 是一家位于波士顿的试剂公司,其主要使命是为QuanQiu科学界提供易于使用的独特实验室研究工具。我们的产品组合包括细胞系、抗体、小分子、染料等,其中许多在其他地方无法获得。自 2011 年成立以来,来自全球 190 多个机构的研究人员通过我们的在线平台提供了他们的创新试剂,无需通过传统的材料转让协议流程即可快速获取材料。

我们处理提供实验室的所有销售和运输物流,并从每次销售中返还丰厚的特许权使用费。因此,我们帮助提供实验室节省时间和资源,同时为进一步研究提供额外资金。采购科学家可以更轻松地发现和获取其他地方通常无法获得的独特试剂,同时还可以资助其他研究人员的工作。这创建了一个QuanQiu科学家社区,他们贡献和获取Reagent for the Greater Good,以加速他们自己的研究以及整体科学进步。

2018 年,Kerafast 与Absolute Antibody合并,后者是一家总部位于英国的公司,其愿景是为所有研究人员提供重组抗体技术。此次合并将两家公司聚集在一起,共同致力于改善科学界可用的研究工具的选择。

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