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Bulk Qty Available.
MW: 81,000 Da
Extinction Coefficient: 1.71
Lyophilized from 20 mM NaP04, pH 7.4, with 10 mg/ml D-Mannitol and 10 mg/ml NaCl.
Plasmin functions in fibrinolysis, fibrinogenolysis, as well as in the complement cascade. This protease has been prepared by using streptokinase to activate human plasma plasminogen.
Min. Activity (pre freeze/lyophilization): 15 units/mg protein
Min. Activity (post lyophilization): 10 units/mg protein
One unit is defined as the amount of enzyme that hydrolyzes one umole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8.
Note: One unit=1.25 CU.
Storage:
Synonym: Fibrinolysin
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Lab products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
Product Citations:
Li, Qun, Tatiana Syrovets, Thomas Simmet, Jiazeng Ding, Jianzhong Xu, Wendong Chen, Dingliang Zhu, and Pingjin Gao. "Plasmin induces intercellular adhesion molecule 1 expression in human endothelial cells via nuclear factor-κB/mitogen-activated protein kinases-dependent pathways. Experimental Biology and Medicine 238, no. 2 (2013): 176-186.
Li, Qun, Yves Laumonnier, Tatiana Syrovets, and Thomas Simmet. "Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages". Acta biochimica et biophysica Sinica(2013).
Shuster, Katherine A., Shirley K. Wrobleski, Angela E. Hawley, Benedict R. Lucchesi, Dorothy R. Sorenson, Ingrid L. Bergin, Robert E. Sigler et al. "Prothrombotic Effects of Thrombolytic Therapy in a Rat (Rattus norvegicus) Model of Venous Thrombolysis.Comparative medicine 63, no. 3 (2013): 244-251.
