- 4 次围观
产品图片
货号/SKU
NR-720
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、2
产品描述信息
NR-720?? Ricin Toxin, Isolated from Ricinus communis Seeds(Toxins)|Ricinus communis|Ricin Toxin, Isolated from Ricinus communis Seeds|2 to 8°C|ES VitettaAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Ricin Toxin, Isolated from Ricinus communis Seeds, NR-720."|Extremely toxic - any exposure may be fatal! Exercise caution! Do not lyophilize!
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Ricin toxin is a glycoprotein isolated from the seeds of Ricinus communis (R. communis), the castor bean plant. It is one of the most toxic and easily produced plant toxins. Ricin toxin consists of two polypeptide chains, A and B, linked by a disulfide bond. The A chain catalytically inactivates the eukaryotic 28S ribosomal RNA subunit, resulting in the inhibition of protein synthesis and death of the cell. The B chain is responsible for receptor binding and delivery of the toxin to the target cell. The sequence for the R. communis gene for the ricin toxin precursor protein has been reported (GenBank: X03179). The crystal structure for ricin toxin has been solved at 2.50 ? resolution (PDB: 2AAI). Ricin toxin has a molecular weight of approximately 63,000 daltons.
NR-720 reacts with a polyclonal antibody to recombinant ricin A chain as determined by radioimmunoassay. NR-720 is active in an in vitro cell-free protein synthesis inhibition assay, an in vitro cytotoxicity assay using human lymphoma cells and an in vivo toxicity assay in mice.
Each vial of NR-720 contains approximately 5 mg of ricin toxin suspended in 0.2 M sodium acetate buffer, pH 3.5.
For information about toxin amounts excluded from CDC Select Agent regulations, click here.
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Ricin toxin is a glycoprotein isolated from the seeds of Ricinus communis (R. communis), the castor bean plant. It is one of the most toxic and easily produced plant toxins. Ricin toxin consists of two polypeptide chains, A and B, linked by a disulfide bond. The A chain catalytically inactivates the eukaryotic 28S ribosomal RNA subunit, resulting in the inhibition of protein synthesis and death of the cell. The B chain is responsible for receptor binding and delivery of the toxin to the target cell. The sequence for the R. communis gene for the ricin toxin precursor protein has been reported (GenBank: X03179). The crystal structure for ricin toxin has been solved at 2.50 ? resolution (PDB: 2AAI). Ricin toxin has a molecular weight of approximately 63,000 daltons.
NR-720 reacts with a polyclonal antibody to recombinant ricin A chain as determined by radioimmunoassay. NR-720 is active in an in vitro cell-free protein synthesis inhibition assay, an in vitro cytotoxicity assay using human lymphoma cells and an in vivo toxicity assay in mice.
Each vial of NR-720 contains approximately 5 mg of ricin toxin suspended in 0.2 M sodium acetate buffer, pH 3.5.
For information about toxin amounts excluded from CDC Select Agent regulations, click here.
主要内容
极其毒性 - 任何曝光可能是致命的！谨慎！不要冻干！
此项目的每个订单数量限制为1.此商品可以每年订购两次.此限制的订单将在发货前发送到NIAID批准.
蓖麻毒素是一种糖蛋白，从蓖麻植物蓖麻植物中的 ricinus communis（R. communis）的种子中分离出来.它是最有毒且易于生产的植物毒素之一.蓖麻毒素
由两个多肽链，A和B组成，通过二硫键连接.链条催化灭活真核28s核糖体RNA亚基，导致抑制细胞的蛋白质合成和死亡. B链负责受体结合和毒素向靶细胞递送. r的序列.报告了蓖麻毒素毒素前体蛋白的Communis （Genbank： x03179 ）.蓖麻毒素的晶体结构已经解决了2.50埃分辨率（PDB： 2aai ）.丽锡
毒素的分子量约为63,000道尔顿.
NR-720与通过放射免疫测定法测定的重组蓖麻抗体的多克隆抗体反应. NR-720在体外的体外蛋白质合成抑制测定中是活性的，使用人淋巴瘤细胞和体内体外毒性测定的在体内毒性测定>小鼠毒性测定.
每个小瓶NR-720含有约5mg蓖麻毒素悬浮在0.2米乙酸钠缓冲液中，pH 3.5.
有关从CDC中排除的毒素金额的信息，请选择代理规则，点击此处.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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