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产品图片
货号/SKU
NR-14815
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、3
产品描述信息
NR-14815??Brucella abortus, 2308 ΔilvC(Bacteria)|Brucella abortus|2308 ΔilvC|-60°C or colder|E ParamithiotisAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Brucella abortus, Strain 2308 ΔilvC, NR-14815."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Brucella abortus (B. abortus), strain 2308 ΔilvC was generated from strain 2308 by deletion of the ilvC gene and replacement with a marker gene encoding resistance to kanamycin. B. abortus, strain 2308 is a well-studied standard laboratory biovar 1 strain, isolated in the USA, that is known to be virulent for humans, cattle and other domestic animals.
The ilvC protein is a ketol-acid reductoisomerase involved in the biosynthesis of leucine, isoleucine and valine [locus tag: BAB_RS22610 (previously, locus tag: BAB1_1399)]. The ilvC deletion in B. abortus, strain 2308, resulted in the attenuation of the strain for infection of murine macrophages (RAW264.7) which was determined by the contributor through an intracellular replication assay. A reduction in virulence has also been noted for a B. melitensisΔilvC strain. The complete genome sequence of B. abortus, strain 2308 is available (GenBank: JMRZ00000000).
Each vial contains approximately 0.7 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.
Brucella abortus (B. abortus), strain 2308 ΔilvC was generated from strain 2308 by deletion of the ilvC gene and replacement with a marker gene encoding resistance to kanamycin. B. abortus, strain 2308 is a well-studied standard laboratory biovar 1 strain, isolated in the USA, that is known to be virulent for humans, cattle and other domestic animals.
The ilvC protein is a ketol-acid reductoisomerase involved in the biosynthesis of leucine, isoleucine and valine [locus tag: BAB_RS22610 (previously, locus tag: BAB1_1399)]. The ilvC deletion in B. abortus, strain 2308, resulted in the attenuation of the strain for infection of murine macrophages (RAW264.7) which was determined by the contributor through an intracellular replication assay. A reduction in virulence has also been noted for a B. melitensisΔilvC strain. The complete genome sequence of B. abortus, strain 2308 is available (GenBank: JMRZ00000000).
Each vial contains approximately 0.7 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.在此限制上订单将在发货前发送至NIAID进行批准. Brucella abortus（B. abortus），通过缺失 ilvc来源2308δ从菌株2308产生菌株2308δ1. / i>基因和用编码对卡那霉素的抗性的标志物基因替代. b. Abortus ，菌株2308是一家学习的标准实验室Biovar 1菌株，众所周知，众所周知的人类，牛和其他家畜的毒性. ILVC蛋白是一种Ketol-酸还原酶酶涉及亮氨酸的生物合成，异亮氨酸和缬氨酸[洛杉矶标签：BAB_RS22610（以前，轨迹标签：BAB1_1399）]. ilvc 在 b中删除. Abortus ，菌株2308导致抑制鼠巨噬细胞感染的菌株（Raw264.7），其由贡献者通过细胞内复制测定法测定.对于A> B也已经注意到毒力的降低. Melitensis δ ilvc 菌株. b的完整基因组序列. abortus ，应变2308可用（genbank： jmrz00000000 ）. 每个小瓶在补充有10％甘油的胰蛋白酶大豆肉汤中含有大约0.7毫升的细菌培养.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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