产品描述信息
NR-45918??Staphylococcus aureus, MN8(Bacteria)|Staphylococcus aureus|MN8|-60°C or colder|G BohachAcknowledgment for publications should read "The following reagent was provided by the Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA) for distribution by BEI Resources, NIAID, NIH: Staphylococcus aureus, Strain MN8, NR-45918."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.Staphylococcus aureus (S. aureus), strain MN8 (also referred to as NRS112) was isolated in 1980 from a patient with toxic shock syndrome-1 in Minnesota, USA.S. aureus, strain MN8 is a methicillin-sensitive S. aureus (MSSA) strain. Strain MN8 was deposited as positive for tsst, ica and hla; negative for mec and PVL; MLST sequence type (ST) 30; pulsed-field type USA200; eGenomic spa type 33, eGenomic spa repeats WGKAKAOMQQ; Ridom spa type t012. S. aureus, strain MN8 has a mutation in agr that results in the attenuation of RNA III, reducing its virulence. It also has a mutation in the α-toxin gene, hla, leading to a large reduction in α-toxin produced. The absence of the wild-type α-toxin inhibits biofilm production, however, this strain is still able to grow to a high density and remains proinflammatory. Therefore, this strain has been termed a high density pathogenic variant (HDPV). The complete genome sequence of S. aureus, strain MN8 is available (GenBank:
ACJA02000001).Each vial contains approximately 0.5 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.