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Bulk Qty Available.
MW: 50,000
Extinction Coefficient: 1.35
Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
Isolated fab fragments can be used to bind antigen to antibody in solution or on the cell surface without causing the undesired complications of cross-linking and precipitation, or "patching" and capping," respectively.
Storage:
Purity: >=95% by SDS-PAGE. No reaction by IEP to antisera to human IgG-fc.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Lab products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
Product Citations:
Franco, Andrea, et al. "Human Fc Receptor–Like 5 Binds Intact IgG via Mechanisms Distinct from Those of Fc Receptors."The Journal of Immunology?190, no. 11 (2013): 5739-5746.
Cattepoel, Susann, et al. "Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro."?PloS one?8, no. 5 (2013): e63162.
Patel, Ashaben, et. al. "A novel approach for antibody nanocarriers development through hydrophobic ion-pairing complexation."?Journal of Microencapsulation?0 (2014): 1-9.
Padmanabhan A, et al. Intravenous immunoglobulin for the treatment of severe refractory heparin induced thrombocytopenia. Chest, Available online 17 April 2017 in press, corrected proof.
Fletcher NA, Babcock LR, Murray EA, Krebs MD. Controlled delivery of antibodies from injectable hydrogels. Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:801-806. doi: 10.1016/j.msec.2015.10.096. Epub 2015 Oct 30.
Ref:
Ricardo, M. J. et al. 1984. Clinical Diagnosis and Management by Laboratory Methods (J.B. Henry, ed.), 860; Poljak, R.J. 1985. Methods Enzymol. 116, 190.
