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产品图片
货号/SKU
NR-28621
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质，其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类：美国、2
产品描述信息
NR-28621?? Influenza A Virus, A/Hong Kong/1/1968-1 Mouse-Adapted 12 (H3N2)(Viruses)|Influenza A virus|Influenza A Virus, A/Hong Kong/1/1968-1 Mouse-Adapted 12 (H3N2)|-60°C or colder|EG BrownAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Influenza A Virus, A/Hong Kong/1/1968-1 Mouse-Adapted 12 (H3N2), NR-28621."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Influenza A virus, A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2) was derived from a virus isolated from a human in Hong Kong on July 17, 1968.
Sequence information is available for influenza A virus, A/Hong Kong/1-1-MA-12/1968 (H3N2) at the Influenza Research Database.
The prototype strain of the 1968 influenza epidemic in Hong Kong was originally isolated in primary monkey kidney cells by W. K. Chang and sent to H. G. Pereira at the WHO World Influenza Center in London, from whom it was subsequently obtained by the Laboratory Center for Disease Control, Health Canada, Ottawa. The virus was passaged twice in rhesus monkey kidney cells and three times in the allantoic cavity of embryonated chicken eggs before two plaque purifications in Madin-Darby canine kidney (MDCK) cells. The cloned virus (available as BEI Resources NR-28620) was then inoculated intranasally into CD-1 mice and virus extracts were prepared from lung homogenates after three days. After twelve sequential mouse passages, a clonal isolate was obtained by two plaque purifications in MDCK cells. The mouse-adapted virus was passaged twice in specific pathogen free embryonated chicken eggs before deposit to BEI Resources. Specific mutations in several viral genes are associated with adaptation to the mouse lung and evolution to increased virulence. Other mutations, or combinations of mutations, are unique to certain isolates, and can be used to identify each individual mouse-adapted variant.
Note that although NR-28621 was deposited to BEI Resources as A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2), nucleotide sequence obtained from the same source material by the NIAID Influenza Genome Sequencing Consortium was deposited to NCBI and IRD as A/Hong Kong/1-1-MA-12/1968 (H3N2).
Each vial contains approximately 1 mL of pooled allantoic fluid from specific pathogen free (SPF) embryonated chicken eggs infected with influenza A virus, A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2).
Influenza A virus, A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2) was derived from a virus isolated from a human in Hong Kong on July 17, 1968.
Sequence information is available for influenza A virus, A/Hong Kong/1-1-MA-12/1968 (H3N2) at the Influenza Research Database.
The prototype strain of the 1968 influenza epidemic in Hong Kong was originally isolated in primary monkey kidney cells by W. K. Chang and sent to H. G. Pereira at the WHO World Influenza Center in London, from whom it was subsequently obtained by the Laboratory Center for Disease Control, Health Canada, Ottawa. The virus was passaged twice in rhesus monkey kidney cells and three times in the allantoic cavity of embryonated chicken eggs before two plaque purifications in Madin-Darby canine kidney (MDCK) cells. The cloned virus (available as BEI Resources NR-28620) was then inoculated intranasally into CD-1 mice and virus extracts were prepared from lung homogenates after three days. After twelve sequential mouse passages, a clonal isolate was obtained by two plaque purifications in MDCK cells. The mouse-adapted virus was passaged twice in specific pathogen free embryonated chicken eggs before deposit to BEI Resources. Specific mutations in several viral genes are associated with adaptation to the mouse lung and evolution to increased virulence. Other mutations, or combinations of mutations, are unique to certain isolates, and can be used to identify each individual mouse-adapted variant.
Note that although NR-28621 was deposited to BEI Resources as A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2), nucleotide sequence obtained from the same source material by the NIAID Influenza Genome Sequencing Consortium was deposited to NCBI and IRD as A/Hong Kong/1-1-MA-12/1968 (H3N2).
Each vial contains approximately 1 mL of pooled allantoic fluid from specific pathogen free (SPF) embryonated chicken eggs infected with influenza A virus, A/Hong Kong/1/1968-1 mouse-adapted 12 (H3N2).
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.在此限制上订单将在发货前发送到NIAID进行批准. 流感病毒，A /香港/ 1/1968-1鼠标适应12（H3N2）衍生自病毒1968年7月17日从香港隔离的人. =“http://www.fludb.org/brc/home.spg?strainname=a/hong%2520kong/1-1-ma-12/… (h3n2）& ;decorator=influenza & context=1393421891988”>流感研究数据库随后由实验室疾病控制，卫生加拿大，渥太华获得的人.病毒在恒河猴肾细胞中传代两次，并在胚胎鸡蛋的两次斑块净化之前在Madin-Darby犬肾（MDCK）细胞中的两次斑块腔内进行了三次.然后将克隆病毒（可用作BEI资源NR-28620）鼻内接种到CD-1小鼠中，并且在三天后从肺匀浆制备病毒提取物.在十二次顺序鼠标通道后，通过MDCK细胞中的两个斑块纯化获得克隆分离??物.在沉积到BEI资源之前，将小鼠适应的病毒在特定病原体自由胚胎鸡蛋中传代两次.几种病毒基因中的特异性突变与对小鼠肺的适应性相关，以增加毒力.其他突变或突变的组合，对某些分离株是独一无二的，并且可用于识别每个单独的鼠标适应变体. 注意虽然沉积了NR-28621作为A /香港/ 1/1968-1鼠标适应的12（H3N2），由NIAID流感基因组测序结社的相同源材料获得的核苷酸序列被沉积在NCBI和IRD中，为A / HONG Kong / 1 -1-MA-12/1968（H3N2）. 每个小瓶含有来自特定病原体（SPF）胚胎鸡蛋感染血型病毒，a /香港/ 1/1968-1鼠标适应12（H3N2）.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立，旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中，可以监控科学界对这些材料的访问和使用，并确保试剂的质量控制。
除了为传染病界提供材料外，BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势，包括安全存储、社区访问和分发；同时保护存款人的知识产权。只要有需要，BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月， ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料，包括由其他政府支持的研究项目存放的材料，将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中，涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
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