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Synonym: AGP, Orosomucoid
MW: ~45,000 Da under Reducing and Non-Reducing Conditions by SDS-PAGE
Extinction Coefficient: 0.89 (0.1% solution, 1 cm path length)
Salt-free lyophilized solid
Storage:
Alpha 1 Acid Glycoprotein A1AGP, AGP, OMD purified from Human plasma. Buy direct from the manufacturer.
Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein:haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.
Ref: Schmid, K. et al. 1973. Biochemistry. 12, 2711; Putnam, F.W. 1984. The Plasma Proteins. (Putnam, F.W., ed.) 2nd Ed. Vol. IV, 5.
Purity: >=95% by SDS-PAGE
Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Lab products are laboratory reagents and are not to be administered to humans or used for any drug purpose.
For research use or for use in further manufacturing.
Product Citations:
Brown, L. J., et al. "Miniaturized ultra high field asymmetric waveform ion mobility spectrometry combined with mass spectrometry for peptide analysis."?Analytical chemistry?82.23 (2010): 9827-9834.
Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR.
Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies.
J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.
