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内容形式：摘要译文
越来越多的证据表明，母体宫内环境会对后代神经发育产生持久影响。美国的肥胖流行病已影响到近三分之一的孕前女性，这可能使后代易于处于不利的发育环境中。葡萄糖是大脑的主要能量来源，其水平受到易化扩散葡萄糖转运体（GLUTs）的严格调控。然而，目前我们对母体肥胖如何影响围产期脑葡萄糖代谢的认识仍十分有限。我们 hypothesize? maternal obesity is associated with altered expression of key GLUTs and dysregulated energy-sensing mechanisms in fetal brain. Female C57BL/6J mice were randomly assigned to either a control diet (CON) or an obesogenic diet (DIO) (60% kcal from fat, 17.5% kcal from sucrose) for 10 weeks, time-mated with control males, and fed their respective diets throughout gestation. At 18.5 days post coitum, fetal brain tissue was collected for protein analysis. DIO diet did not affect litter size, offspring body weight, or brain weight when compared to CON. Whole brain GLUT1 expression was elevated only in female DIO offspring, while GLUT3 and GLUT4 expression was increased in all DIO offspring without modification by sex. However, maternal diet was not associated with differences in the activation of energy regulatory pathways adenosine monophosphate-activated protein kinase (AMPK) or the nutrient-sensing pathway mechanistic target of rapamycin (mTOR) in the fetal brain. These findings suggest that maternal obesogenic diet alters glucose transporter expression in the fetal brain, indicating a potential disruption in cerebral glucose metabolism during critical periods of perinatal development.
关键词：母体肥胖 · 胎儿脑发育 · 葡萄糖转运体 · 脑葡萄糖代谢 · 能量感知机制 · 小鼠模型
原文链接：https://www.biorxiv.org/content/10.64898/2026.05.11.723868v1?rss=1