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Adv Sci (Weinh). 2026 Aug 31:e77512. doi: 10.1002/advs.77512. Online ahead of print.
ABSTRACT
The choroid plexus (ChP) secretes cerebrospinal fluid (CSF) and forms the blood-CSF barrier (BCSFB), playing indispensable roles in brain development and homeostasis. However, tractable human ChP models remain limited, with current organoid protocols largely overlooking the stem cell niche as a determinant of lineage commitment. Here, we report that a small number of ChP organoids sporadically emerge during skin organoid induction, and switching human embryonic stem cells (hESCs) culture from E8 to mTeSR1 medium-preconditioning cells toward a neural-primed state-substantially enhances ChP organoid induction efficiency from
PMID:42675788 | PMC:PMC13530365 | DOI:10.1002/advs.77512