Clin Case Rep. 2025 Dec 17;13(12):e71288. doi: 10.1002/ccr3.71288. eCollection 2025 Dec.
ABSTRACT
Conjoined twinning is a rare and severe complication of monozygotic pregnancies. Assisted reproductive technologies (ART), including in vitro fertilization (IVF), may increase the risk of such anomalies. We report a case of thoraco-omphalopagus conjoined twins following a day 5 embryo transfer after IVF with intracytoplasmic sperm injection (ICSI). The diagnosis was made by ultrasound at 8 weeks' gestation and confirmed the presence of fused thoracic and abdominal structures with a shared heart. The pregnancy was managed through multidisciplinary counseling, and termination was performed following spontaneous fetal demise. This case underscores the importance of early imaging, detailed embryologic understanding, and coordinated care in managing rare IVF-associated anomalies.
PMID:41415521 | PMC:PMC12710522 | DOI:10.1002/ccr3.71288