Reprod Biomed Online. 2025 Aug 11;52(1):105208. doi: 10.1016/j.rbmo.2025.105208. Online ahead of print.
ABSTRACT
RESEARCH QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) and the transfer of euploid poor-quality blastocysts (PQB) reduce the number of transfers needed to achieve live births compared with the transfer of their untested counterparts?
DESIGN: Single-centre retrospective cohort study conducted between 2015 and 2024 (PGT-A blastocysts: n = 7332 from 2258 cycles; n = 1344). Transfer outcomes were analysed for a subset of 74 cycles involving tested PQB and compared with 192 cycles involving untested PQB during the same period.
RESULTS: High-quality blastocysts (AA, AB, BA and BB) were most likely to be euploid (P
CONCLUSIONS: A clinically relevant proportion of PQB are euploid, PQB can result in live births and euploid transfer is associated with lower miscarriage rates. In combination, this suggests that PQB should not be routinely discarded, particularly if they are prior-tested using PGT-A.
PMID:41435727 | DOI:10.1016/j.rbmo.2025.105208