From form to function: New heights in kidney organoids

Cell Stem Cell. 2025 Oct 2;32(10):1485-1486. doi: 10.1016/j.stem.2025.09.003.

ABSTRACT

In this issue of Cell Stem Cell, Huang et al.¹ address the challenge of creating organoids that more closely replicate kidney spatial patterning and function. They develop region-specific progenitor assembloids mimicking native architecture. After transplantation into mice, which further promotes differentiation, they demonstrate functional and disease modeling capability.

PMID:41043401 | DOI:10.1016/j.stem.2025.09.003