Vascular organoids get a speed boost for regenerative repair

Cell Stem Cell. 2025 Aug 7;32(8):1185-1187. doi: 10.1016/j.stem.2025.07.002.

ABSTRACT

Gong et al. present a transcription factor-guided 3D differentiation that rapidly generates vascular organoids from human iPSCs, enhancing engraftment and revascularization of ischemic limbs and transplanted pancreatic islets in mouse models.¹ This approach establishes a scalable platform for generating functional vasculature, supporting both disease modeling and regenerative therapy development.

PMID:40780186 | DOI:10.1016/j.stem.2025.07.002