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Front Endocrinol (Lausanne). 2025 Jul 30;16:1629837. doi: 10.3389/fendo.2025.1629837. eCollection 2025.
ABSTRACT
OBJECTIVE: To investigate the associations between triglyceride glucose-body mass index (TyG-BMI) and reproductive outcomes in women with polycystic ovary syndrome (PCOS) undergoing frozen embryo transfer (FET).
METHODS: This retrospective cohort study included PCOS women undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycle followed by FET from January 2018 to January 2024 at a single reproductive medicine center. Patients were categorized into four groups according to the quartiles of TyG-BMI. Multivariable logistic regression, restricted cubic splines (RCS) and stratified analyses were used to evaluate the associations between TyG-BMI and reproductive outcomes. LASSO regression was performed to identify predictors for miscarriage and receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive power.
RESULTS: A total of 744 women were included in the analysis. After adjusting for covariates, TyG-BMI showed a negative correlation with live birth rate and positive correlations with the risks of miscarriage and gestational diabetes mellitus (GDM) (all P trend 0.05). These associations remained consistent across all subgroups of the population (all P-interaction > 0.05). ROC analysis revealed that TyG-BMI was predictive of miscarriage (area under the curve (AUC) = 0.627, P 0.650, P 2, AUC = 0.743, P
CONCLUSION: Higher TyG-BMI levels are independently associated with an increased risk of adverse reproductive outcomes in women with PCOS undergoing FET. Additionally, TyG-BMI proves to be a cost-effective tool for the early identification of high-risk groups among PCOS patients, enabling personalized interventions prior to IVF to optimize reproductive outcomes in this population.
PMID:40810075 | PMC:PMC12343246 | DOI:10.3389/fendo.2025.1629837