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Front Endocrinol (Lausanne). 2025 Jul 29;16:1608200. doi: 10.3389/fendo.2025.1608200. eCollection 2025.
ABSTRACT
INTRODUCTION: This study compared pregnancy outcomes after frozen-thawed embryo transfer (FET) in infertile women aged
METHODS: In this retrospective study, we analyzed the data of 1,362 patients aged
RESULTS: After weighting, the clinical pregnancy rate was significantly lower in the DOR group than in the NOR group (47.0% vs. 58.3%, P = 0.040; odds ratio = 0.63, 95% confidence interval: 0.41-0.98). Exploratory analysis revealed that the expression of p16 was significantly higher in the endometrial cells of patients with DOR than in those of patients in the NOR group (P
CONCLUSION: These exploratory findings suggest that reduced pregnancy rates in young women with DOR may involve endometrial aging mechanisms; however, the preliminary nature and limited sample size for molecular analysis necessitate cautious interpretation and warrant validation in larger and well-controlled cohorts.
PMID:40801036 | PMC:PMC12339334 | DOI:10.3389/fendo.2025.1608200