Yang K, Bai HJ, Ouyang Q, Lai LH*, Tang C, Finding multiple target optimal intervention in disease-related molecular network. MOLECULAR SYSTEMS BIOLOGY, 4, 228.1-228.13, 2008.

Abstract Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We appl......