Janka M, He W, Haedicke IE, Fronczek FR, Frontier AJ. Eisenberg R. Tandem Nazarov Cyclization-Michael Addition Sequence Catalyzed by an Ir(III) Complex. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128: 5312-5313, 2006

Abstract The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.......