Fang GM, Li YM, Shen F, Huang YC, Li JB, Lin Y, Cui HK, Liu L.* Protein chemical synthesis via ligation of peptide hydrazides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 2011, in press.

Keywords:native chemical ligation;peptide hydrazides;protein chemical synthesis;protein design;proteins pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a “thioester synthon”, one that is stable to the conditions of native chemical ligation.......