Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. SCIENCE 304(5676):1500-2, 2004

root 提交于 周日, 10/31/2021 - 01:47
Abstract Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.......

相关内容

发布日期 08/04/2020 - 01:35
发布日期 08/04/2020 - 01:35
发布日期 10/17/2023 - 23:16
发布日期 02/18/2025 - 20:47
发布日期 01/18/2025 - 20:37
发布日期 01/31/2024 - 13:01
发布日期 02/29/2024 - 16:35