Abstract The transforming growth factor-β (TGF-β) superfamily of ligands signals along two intracellular pathways, Smad2/3-mediated TGF-β/activin pathway and Smad1/5/8-mediated bone morphogenetic protein pathway. The C terminus of Hsc70-interacting protein (CHIP) serves as an E3 ubiquitin ligase to mediate the degradation of Smad proteins and many other signaling proteins. However, the molecular mechanism for CHIP-mediated down-regulation of TGF-β signaling remains unclear. Here we show that the extreme C-terminal sequence of Smad1 plays an indispensable role in its direct association with the tetratricopeptide repeat (TPR) domain of CHIP. Interestingly, Smad1 undergoes CHIP-mediated polyubiquitination in the absence of molecular chaperones, and phosphorylation of the C-terminal SXS m......
来源出处
Wang L, Liu YT, Hao R, Chen L, Chang Z, Wang HR, Wang ZX, Wu JW*. Molecular mec…
http://218.241.158.84:8088/Research/Articles/index286.shtml
相关内容
发布日期
06/23/2024 - 17:52
发布日期
03/19/2024 - 09:13
发布日期
01/10/2022 - 19:31
发布日期
10/31/2021 - 01:16
发布日期
11/09/2024 - 19:46
发布日期
06/17/2022 - 10:21
发布日期
11/17/2024 - 19:48
发布日期
10/08/2023 - 23:02
发布日期
07/23/2023 - 21:46
发布日期
06/17/2022 - 10:21
发布日期
08/04/2020 - 01:35
发布日期
03/11/2025 - 20:51
发布日期
01/10/2022 - 19:31
发布日期
01/10/2022 - 19:31
发布日期
06/17/2022 - 10:21
发布日期
06/17/2022 - 10:21
发布日期
10/14/2023 - 23:10
发布日期
10/19/2024 - 19:37
发布日期
06/05/2024 - 17:45
发布日期
10/31/2021 - 01:12