Liao Yn, Hu YH, Wu J, Donovan M, Fathi R, Yang Z*, Diversity Oriented Synthesis and Branching Reaction Pathway to Generate Natural Product-like Compounds, CURRENT MEDICINAL CHEMISTRY, 10, 2258, 2003.

Abstract Combinatorial chemistry can be used to synthesize diversified molecules on a large scale. As with all large-scale experiments, this process requires a major investment in equipment, consumables and time. Therefore, careful design is critical. As the complexity of the libraries to be generated increases, additional considerations become important. What are the issues that should be considered when planning combinatorial chemistry projects? Which features in the design strategy are critical to consider ensuring that all of the potential products will be synthesized? How are the reactants selected to optimize product synthesis and yield? Over the last several years, through an experimental process, we have successfully developed and optimized our synthetic strategy. Our approach inc......