Ma WZ, Lai LH, Ouyang Q*, Tang C*, Robustness and modular design of the Drosophila segment polarity network, MOLECULAR SYSTEMS BIOLOGY, 70.1-70.9, 2006.

root 提交于 周日, 10/31/2021 - 01:47
Abstract Biomolecular networks have to perform their functions robustly. A robust function may have preferences in the topological structures of the underlying network. We carried out an exhaustive computational analysis on network topologies in relation to a patterning function in Drosophila embryogenesis. We found that whereas the vast majority of topologies can either not perform the required function or only do so very fragilely, a small fraction of topologies emerges as particularly robust for the function. The topology adopted by Drosophila, that of the segment polarity network, is a top ranking one among all topologies with no direct autoregulation. Furthermore, we found that all robust topologies are modular-each being a combination of three kinds of modules. These modules can be ......

相关内容

发布日期 01/10/2022 - 19:31
发布日期 10/31/2021 - 01:16
发布日期 11/09/2024 - 19:46
发布日期 11/17/2024 - 19:48
发布日期 07/23/2023 - 21:46
发布日期 03/11/2025 - 20:51
发布日期 06/17/2022 - 10:21
发布日期 10/14/2023 - 23:10
发布日期 06/05/2024 - 17:45