Leilei Zhang, Yu Yan, Zijie Liu, Abliz Zeper, Gang Liu*, Identification of Peptide Substrate and Small Molecule Inhibitors of Testis-specific Serine/Threonine Kinase1 (TSSK1) By the Developed Assays, Journal of Medicinal Chemistry, 2009, 52, 4419-4428.

root 提交于 周日, 10/31/2021 - 01:47
Abstract In this paper, a peptide substrate (Pep8) of TSSK1 is identified. Using Pep8 as a substrate, two homogeneous and efficient assays for TSSK1 inhibitors screening have been developed, including luminescent kinase assay and LC-MS-based high-throughput assay. Two classes of compounds were identified that are able to efficiently inhibit phosphorylation catalyzed by TSSK1.......

相关内容

发布日期 08/04/2020 - 01:35
发布日期 08/04/2020 - 01:35
发布日期 10/17/2023 - 23:16
发布日期 02/18/2025 - 20:47
发布日期 01/18/2025 - 20:37
发布日期 01/31/2024 - 13:01
发布日期 02/29/2024 - 16:35