- 3 次围观
Abstract Protein phosphatase 2A (PP2A) is an important serine/threonine phosphatase that plays a role in many biological processes. Reversible carboxyl methylation of the PP2A catalytic subunit is an essential regulatory mechanism for its function. Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from yeast to humans. However, the underlying mechanism of PME-1 function remains enigmatic. Here we report the crystal structures of PME-1 by itself and in complex with a PP2A heterodimeric core enzyme. The structures reveal that PME-1 directly binds to the active site of PP2A and that this interaction results in the activation of PME-1 by rearranging the catalytic triad into an active conformation. Strikingly, these interactio......
来源出处
Xing YN, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi YG. Structural Mechnism of Dem…
http://218.241.158.84:8088/Research/Articles/index277.shtml
相关内容
发布日期
08/04/2020 - 01:35
发布日期
01/10/2022 - 19:32
发布日期
08/04/2020 - 01:35
发布日期
10/31/2021 - 01:12
发布日期
09/05/2024 - 19:28
发布日期
02/18/2025 - 20:48
发布日期
10/17/2023 - 23:16
发布日期
06/17/2022 - 10:21
发布日期
01/10/2022 - 19:31
发布日期
02/18/2025 - 20:47
发布日期
01/18/2025 - 20:37
发布日期
08/04/2020 - 01:35
发布日期
08/04/2020 - 01:35
发布日期
01/31/2024 - 13:01
发布日期
10/31/2021 - 01:48
发布日期
01/10/2022 - 19:31
发布日期
07/19/2023 - 21:44
发布日期
08/04/2020 - 01:35
发布日期
02/29/2024 - 16:35
发布日期
06/17/2022 - 10:21