Yao Ma, Nan Zhao, Gang Liu*, Muramyl Dipeptide’s Derivative and Paclitaxel Conjugate (MTC-220) Simultaneously Prevents Tumor Growth and Metastasis in Mice, Journal of Medicinal Chemistry, 2011, 54(8): 2767-77.

root 提交于 周日, 10/31/2021 - 01:47
Abstract 1 (MTC-220), a conjugate of paclitaxel and a muramyl dipeptide analogue, has been synthesized as a novel agent of dual antitumor growth and metastasis activities. In vitro and in vivo tests show that 1 retains its ability to inhibit tumor growth. It is superior to paclitaxel in its ability to prevent tumor metastasis in Lewis lung carcinoma and 4T1-tumor-bearing mice. The present studies indicate that 1 suppresses myeloid derived suppressor cell accumulation in the spleen and bone marrow of tumor-bearing mice and also represses inflammatory cytokines in tumor tissue. These results demonstrated that 1 could be a potential therapeutic and preventive agent for cancer growth and metastasis."......

相关内容

发布日期 08/04/2020 - 01:35
发布日期 08/04/2020 - 01:35
发布日期 10/17/2023 - 23:16
发布日期 02/18/2025 - 20:47
发布日期 01/18/2025 - 20:37
发布日期 01/31/2024 - 13:01
发布日期 02/29/2024 - 16:35