- 1次围观
Abstract The plasticity of synapses within neural circuits is regulated by activity, but the underlying mechanisms remain elusive. Using the dye FM1-43 to directly image presynaptic function, we found that large numbers of presynaptic terminals in hippocampal cultures have a low release probability. While these terminals were not readily modifiable, a transient but not permanent long-term reduction of network activity or Ca2+ influx could increase their modifiability. This modulation of plasticity was mediated by Ca2+ flux through NMDA and voltage-gated calcium channels and was lost within 48 hr. A more permanent enhancement of synaptic plasticity was achieved by selectively reducing the Ca2+ flux associated with uncorrelated activity via adjustment of the voltage-dependent Mg2+ block of ......
来源出处
Slutsky I, Sadeghpour S, Li B, Liu G. Enhancement of Synaptic Plasticity throug…
http://218.241.158.84:8088/Research/Articles/index223.shtml
相关内容
发布日期
12/12/2023 - 01:18
发布日期
01/21/2024 - 12:12
发布日期
06/17/2022 - 10:21
发布日期
06/17/2022 - 10:21
发布日期
01/10/2022 - 19:31
发布日期
01/22/2024 - 01:44
发布日期
06/17/2022 - 10:21
发布日期
08/23/2024 - 19:21
发布日期
06/17/2022 - 10:21
发布日期
08/18/2024 - 19:19
发布日期
08/04/2020 - 01:35
发布日期
06/17/2022 - 10:21
发布日期
08/04/2020 - 01:35
发布日期
06/17/2022 - 10:21
发布日期
09/10/2023 - 22:37
发布日期
10/31/2021 - 01:12
发布日期
10/31/2021 - 01:48
发布日期
06/17/2022 - 10:21
发布日期
10/12/2023 - 23:10
发布日期
08/04/2020 - 01:35