- 1次围观
Abstract The plasticity of synapses within neural circuits is regulated by activity, but the underlying mechanisms remain elusive. Using the dye FM1-43 to directly image presynaptic function, we found that large numbers of presynaptic terminals in hippocampal cultures have a low release probability. While these terminals were not readily modifiable, a transient but not permanent long-term reduction of network activity or Ca2+ influx could increase their modifiability. This modulation of plasticity was mediated by Ca2+ flux through NMDA and voltage-gated calcium channels and was lost within 48 hr. A more permanent enhancement of synaptic plasticity was achieved by selectively reducing the Ca2+ flux associated with uncorrelated activity via adjustment of the voltage-dependent Mg2+ block of ......
来源出处
Slutsky I, Sadeghpour S, Li B, Liu G. Enhancement of Synaptic Plasticity throug…
http://218.241.158.84:8088/Research/Articles/index223.shtml
相关内容
发布日期
08/04/2020 - 01:35
发布日期
06/17/2022 - 10:21
发布日期
06/22/2024 - 17:53
发布日期
01/10/2022 - 19:32
发布日期
09/21/2023 - 22:52
发布日期
02/10/2022 - 15:24
发布日期
01/10/2022 - 19:31
发布日期
08/04/2020 - 01:35
发布日期
10/23/2024 - 19:39
发布日期
09/02/2024 - 19:26
发布日期
08/04/2020 - 01:35
发布日期
08/04/2020 - 01:35
发布日期
06/07/2024 - 17:46
发布日期
08/20/2024 - 19:21
发布日期
10/31/2021 - 01:12
发布日期
04/18/2024 - 09:29
发布日期
08/04/2020 - 01:35
发布日期
09/18/2024 - 19:30
发布日期
09/02/2024 - 19:26
发布日期
07/02/2023 - 18:27