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产品图片
货号/SKU
NR-48768
货号/规格
EA
库存与交货期
3-8周
人民币价格
14000
试剂海关审批
A/B级风险物质只能直接使用人购买并持有实验室有效资质,其它询客服确认
国外采购
支持/部分限制一年内购买数量
厂牌
BEI Resources(ATCC)
产品基础信息
生物安全等级建议分类:美国、2
产品描述信息
NR-48768??Cryptococcus neoformans, KN99a(Fungi)|Cryptococcus neoformans|KN99a|-130°C or colder|J HeitmanAcknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Cryptococcus neoformans, Strain KN99a, NR-48768."|Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Cryptococcus neoformans (C. neoformans), strain KN99a was derived from strain H99O (BEI Resources NR-48767), after passage in the rabbit model of central nervous system infection. C. neoformans, strain H99 was isolated from the cerebrospinal fluid of a human male who had been treated for Hodgkin's disease in North Carolina, USA on February 14, 1978. After an unknown number of passages, strain H99 was reported to lose virulence and was subsequently passaged through the rabbit model of infection to increase its virulence. It was renamed as H99O and frozen in 1994.
C. neoformans var. grubii, strain H99O (H99) was sequenced in 2014 through a collaboration between Duke University and the Broad Institute (NCBI BioProject: PRJNA411). Strain H99O is the progenitor of nine phenotypic variants that display either increased or decreased mating ability, melanization and virulence.
C. neoformans, strain KN99a was derived from strain H99O concurrently with the congenic strain KN99α (BEI Resources NR-48769). The congenic pair was created by backcrossing strain H99O with strain H99F (BEI Resources NR-48770).
Each vial contains approximately 0.5 mL of C. neoformans in 20% glycerol.
Cryptococcus neoformans (C. neoformans), strain KN99a was derived from strain H99O (BEI Resources NR-48767), after passage in the rabbit model of central nervous system infection. C. neoformans, strain H99 was isolated from the cerebrospinal fluid of a human male who had been treated for Hodgkin's disease in North Carolina, USA on February 14, 1978. After an unknown number of passages, strain H99 was reported to lose virulence and was subsequently passaged through the rabbit model of infection to increase its virulence. It was renamed as H99O and frozen in 1994.
C. neoformans var. grubii, strain H99O (H99) was sequenced in 2014 through a collaboration between Duke University and the Broad Institute (NCBI BioProject: PRJNA411). Strain H99O is the progenitor of nine phenotypic variants that display either increased or decreased mating ability, melanization and virulence.
BEI Resources Number | Strain Name | Mating Ability/Melanization Virulence |
---|---|---|
NR-48767 | H99O | N/A |
NR-48768 | KN99a | Increased |
NR-48769 | KN99a | Increased |
NR-48770 | H99F | Increased |
NR-48771 | H99C | Decreased |
NR-48772 | H99S | Increased |
NR-48773 | H99W | Decreased |
NR-48774 | H99ED | Decreased |
NR-48775 | H99E | Decreased |
NR-48776 | YL99a | Increased |
NR-48777 | YL99a | Increased |
C. neoformans, strain KN99a was derived from strain H99O concurrently with the congenic strain KN99α (BEI Resources NR-48769). The congenic pair was created by backcrossing strain H99O with strain H99F (BEI Resources NR-48770).
Each vial contains approximately 0.5 mL of C. neoformans in 20% glycerol.
主要内容
此项目的每个订单数量限制为1.此商品每年可订购两次.此限制的订单将在发货前发送到NIAID进行批准. 加线核科族新族制症(C. neoformans),菌株KN99a源自菌株H99O(BEI资源NR -48767),在中枢神经系统感染的兔模型之后通过. c. Neoformans ,菌株H99从1978年2月14日在美国在美国北卡罗来纳州治疗的人类患者的脑脊液中分离出来.经过一个未知数量的通道,据报道,菌株H99丧失毒力随后通过兔子感染模型传代,以增加其毒力.它被重新命名为H99O和1994年冻结. c. Neoformans var. Grubii ,菌株H99O(H99)通过Duke University和Broad Institute(NCBI Bioproject: prjna411 ).菌株H99O是九种表型变体的祖祖,显示出增加或减少交配能力,黑素化和毒力.
bei资源编号  
应变名称  
交配能力/黑色化毒力
nr-48767
h99O
n / a
nr-48768
KN99A
增加
nr-48769
KN99A
增加
nr-48770
h99f
增加
nr-48771
h99c
减少
nr-48772
h99s
增加
nr-48773
h99w
减少
nr-48774
h99ed
减少
nr-48775
h99e
减少
nr-48776
yl99a
增加
NR-48777
yl99a
增加
c.
Neoformans, 应变KN99A与Concenic同时衍生自菌株H99O
应变KN99α(BEI资源NR-48769). Congenic对是由
rescrossing菌株H99O具有菌株H99F(Bei Resources NR-48770). 每个小瓶含有约0.5毫升 c. Neoformans 在20%甘油中.
厂牌介绍
BEI Resources 由美国国家过敏和传染病研究所 ( NIAID )成立,旨在为研究 A、B 和 C 类优先病原体、新兴传染病病原体、非病原微生物和其他相关微生物材料提供试剂、工具和信息到研究界。BEI Resources 获取、验证和生产科学家进行基础研究和开发改进的诊断测试、疫苗和疗法所需的试剂。通过将这些功能集中在 BEI Resources 中,可以监控科学界对这些材料的访问和使用,并确保试剂的质量控制。
除了为传染病界提供材料外,BEI Resources 还鼓励和支持研究人员和机构的材料存放。使用 BEI Resources存放材料对研究人员和研究社区有许多优势,包括安全存储、社区访问和分发;同时保护存款人的知识产权。只要有需要,BEI 资源库将作为研究人员的资源进行维护。您在 BEI Resources 的存款是一项有助于未来研究的长期投资。
BEI Resources 自 2003 年起由美国典型培养物保藏中心 (ATCC) 根据合同管理。2016 年 5 月, ATCC获得了一份为期七年的继续管理 BEI Resources的合同。合同范围已扩大到更全面的研究目录材料,包括由其他政府支持的研究项目存放的材料,将提供给生物防御和新兴传染病科学界。真菌、寄生虫、载体和其他相关材料已添加到现有的细菌、病毒和毒素试剂中,涵盖 NIAID A、B 和 C 类优先病原体和 NIAID 指定的新发传染病病原体和生物。
品牌标识
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